Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 5/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 5/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.30 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1363486 | 0.84 | GABRA1 (0.50) | GABRA1GABRB2LMNASMN1; SMN2L3MBTL1 | |
| SCHEMBL6285101 | 0.78 | GABRA1 (0.44) | GABRA1GABRB2LMNASMN1; SMN2L3MBTL1 | |
| SCHEMBL16951737 | 0.75 | GABRA1 (0.46) | GABRA1GABRB2LMNASMN1; SMN2L3MBTL1 | |
| SCHEMBL24063978 | 0.75 | GABRA1 (0.41) | GABRA1GABRB2LMNASMN1; SMN2 | |
| SCHEMBL420437 | 0.72 | GABRA1 (0.43) | GABRA1GABRB2LMNASMN1; SMN2L3MBTL1 | |
| SCHEMBL2775950 | 0.72 | GABRA1 (0.43) | GABRA1GABRB2SMN1; SMN2 | |
| SCHEMBL26028903 | 0.71 | ALDH1A1 (0.46) | GABRA1GABRB2 | |
| SCHEMBL11771453 | 0.71 | GABRA1 (0.52) | GABRA1GABRB2 | |
| SCHEMBL24061530 | 0.70 | GABRA1 (0.42) | GABRA1GABRB2LMNASMN1; SMN2 | |
| SCHEMBL16952549 | 0.70 | GABRA1 (0.38) | GABRA1GABRB2LMNASMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3436460-B1 | FUSED PENTACYCLIC IMIDAZOLE DERIVATIVES AS MODULATORS OF TNF ACTIVITY | UCB Biopharma SRL (BE) | 2021-08-18 | — | — | EP | disclosed |