Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR9 | Q9NR96 | 5/20 | 0.51 |
| ▸ | TLR7 | Q9NYK1 | 5/20 | 0.51 |
| ▸ | TLR8 | Q9NR97 | 4/20 | 0.51 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.31 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.31 |
| ▸ | CDC42BPB | Q9Y5S2 | 4/20 | 0.31 |
| ▸ | NOS2 | P35228 | 4/20 | 0.31 |
| ▸ | CDC42BPA | Q5VT25 | 2/20 | 0.31 |
| ▸ | NOS3 | P29474 | 3/20 | 0.31 |
| ▸ | NOS1 | P29475 | 3/20 | 0.31 |
| ▸ | AR | P10275 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23628752 | 0.87 | TLR9 (0.41) | TLR9TLR7TLR8KDRSYK | |
| SCHEMBL23760671 | 0.80 | NCF1 (0.34) | TLR9TLR7TLR8 | |
| SCHEMBL23628806 | 0.76 | TLR9 (0.45) | TLR9TLR7TLR8SYKROCK2 | |
| SCHEMBL23628865 | 0.76 | TLR9 (0.38) | TLR9TLR7TLR8KDRSYK | |
| SCHEMBL23760691 | 0.75 | TLR9 (0.43) | TLR9TLR7TLR8KDRSYK | |
| SCHEMBL26272594 | 0.73 | TLR8 (0.55) | TLR9TLR7TLR8ROCK2ROCK1 | |
| SCHEMBL21795383 | 0.73 | TLR9 (0.78) | TLR9TLR7TLR8 | |
| SCHEMBL21795387 | 0.73 | TLR9 (0.78) | TLR9TLR7TLR8 | |
| SCHEMBL20658625 | 0.73 | TLR8 (0.54) | TLR9TLR7TLR8 | |
| SCHEMBL20670315 | 0.73 | TLR8 (0.54) | TLR9TLR7TLR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210253575-A1 | PYRROLIDINE AMINE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE | HOFFMANN-LA ROCHE INC. (US) | 2021-08-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210253575-A1 | PYRROLIDINE AMINE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE | ARG1, PRMT1, PADI1 | TLR9 308/4885TLR7 229/4885TLR8 1800/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.