Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 18/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11223045 | 1.00 | TBXAS1 (0.70) | TBXAS1 | |
| SCHEMBL2946530 | 0.98 | TBXAS1 (0.67) | TBXAS1 | |
| SCHEMBL5858630 | 0.92 | TBXAS1 (0.63) | TBXAS1 | |
| Hydrochloric Acid SCHEMBL17746653 | 0.91 | TBXAS1 (0.61) | TBXAS1 | |
| SCHEMBL285054 | 0.84 | TBXAS1 (1.00) | TBXAS1 | |
| SCHEMBL2535103 | 0.84 | TBXAS1 (1.00) | TBXAS1 | |
| SCHEMBL2533366 | 0.84 | TBXAS1 (1.00) | TBXAS1 | |
| SCHEMBL10247600 | 0.84 | TBXAS1 (1.00) | TBXAS1 | |
| SCHEMBL939851 | 0.84 | TBXAS1 (1.00) | TBXAS1 | |
| SCHEMBL1679410 | 0.84 | TBXAS1 (1.00) | TBXAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190169342-A1 | POLYIMIDAZOLES FOR USE AS BILE ACID SEQUESTRANTS | RELYPSA, INC. | 2019-06-06 | — | — | US | disclosed |
| EP-3130343-B1 | POLYIMIDAZOLES FOR USE AS BILE ACID SEQUESTRANTS | RELYPSA INC (US) | 2018-05-09 | — | — | EP | disclosed |
| EP-3130343-A1 | POLYIMIDAZOLES FOR USE AS BILE ACID SEQUESTRANTS | Relypsa, Inc. (US) | 2017-02-15 | — | — | EP | disclosed |
| EP-2538947-B1 | POLYIMIDAZOLES FOR USE AS BILE ACID SEQUESTRANTS | RELYPSA INC (US) | 2016-08-17 | — | — | EP | disclosed |
| US-20130189215-A1 | POLYIMIDAZOLES FOR USE AS BILE ACID SEQUESTRANTS | RELYPSA, INC. (US) | 2013-07-25 | — | — | US | disclosed |
| EP-2538947-A1 | POLYIMIDAZOLES FOR USE AS BILE ACID SEQUESTRANTS | Relypsa, Inc. (US) | 2013-01-02 | — | — | EP | disclosed |
| CN-102858347-A | Polyimidazoles as bile acid sequestrants | RELYPSA INC | 2013-01-02 | — | — | CN | disclosed |
| WO-2011106545-A1 | POLYIMIDAZOLES FOR USE AS BILE ACID SEQUESTRANTS | RELYPSA, INC. (US) | 2011-09-01 | — | — | WO | disclosed |
| US-4320134-A | HYPOTENSIVE, ANTIASTHMATIC AND ANTIINFLAMMATORY AGENTS | ONO PHARMACEUTICAL CO., LTD. (JP) | 1982-03-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130189215-A1 | POLYIMIDAZOLES FOR USE AS BILE ACID SEQUESTRANTS | NR1H4, SLC10A2, ITCH | TBXAS1 2184/4885 |
| US-20190169342-A1 | POLYIMIDAZOLES FOR USE AS BILE ACID SEQUESTRANTS | NR1H4, SLC10A2, ITCH | TBXAS1 2184/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.