Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 3/20 | 0.65 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.65 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6926430 | 0.81 | KMT2A (0.48) | CCR5SIGMAR1HPGDTSHRCHRM1 | |
| SCHEMBL11331947 | 0.77 | SIGMAR1 (0.51) | CCR5SIGMAR1NPC1RAB9AALDH1A1 | |
| SCHEMBL2405208 | 0.77 | SIGMAR1 (0.60) | CCR5SIGMAR1HPGDTSHRCHRM1 | |
| SCHEMBL4283829 | 0.77 | CCR5 (0.62) | CCR5SIGMAR1HPGDKMT2AALDH1A1 | |
| SCHEMBL2408117 | 0.77 | KMT2A (0.52) | CCR5SIGMAR1CHRM1KMT2AMAPT | |
| SCHEMBL13434158 | 0.74 | SIGMAR1 (0.47) | CCR5SIGMAR1KMT2AMEN1ALDH1A1 | |
| SCHEMBL2404021 | 0.73 | SIGMAR1 (0.62) | CCR5SIGMAR1HPGDTSHRKMT2A | |
| SCHEMBL19444606 | 0.73 | CCR5 (0.64) | CCR5HPGDTSHRCHRM1KMT2A | |
| SCHEMBL27499172 | 0.73 | NPC1 (0.52) | SIGMAR1HPGDTSHRKMT2AMEN1 | |
| SCHEMBL19658975 | 0.73 | CCR5 (0.58) | CCR5SIGMAR1KMT2AMEN1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3464286-B1 | PYRAZOLOPYRIDINE DERIVATIVES FOR THE TREATMENT OF CANCER | GENENTECH INC (US) | 2021-08-18 | — | — | EP | disclosed |