Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL2 | P60568 | 2/20 | 0.39 |
| ▸ | JAK2 | O60674 | 8/20 | 0.39 |
| ▸ | JAK3 | P52333 | 5/20 | 0.39 |
| ▸ | PTK2 | Q05397 | 5/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | CTSC | P53634 | 1/20 | 0.36 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.35 |
| ▸ | PDE2A | O00408 | 1/20 | 0.35 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.33 |
| ▸ | DYRK2 | Q92630 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.33 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.33 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23764045 | 0.80 | IL2 (0.52) | IL2JAK2NPY5RJAK1BRAF | |
| SCHEMBL23764044 | 0.78 | EGLN2 (0.44) | JAK2JAK3NUDT1JAK1 | |
| SCHEMBL2635059 | 0.64 | JAK2 (0.56) | JAK2JAK3PTK2PDE2ADYRK1A | |
| SCHEMBL2634386 | 0.62 | JAK2 (0.56) | JAK2JAK3PTK2DYRK1ADYRK2 | |
| SCHEMBL2640360 | 0.60 | JAK2 (0.56) | JAK2JAK3PTK2NUDT1PDE2A | |
| SCHEMBL2634343 | 0.60 | JAK2 (0.56) | JAK2JAK3PTK2PDE2ADYRK1A | |
| SCHEMBL19785385 | 0.59 | PDE2A (0.47) | IL2PDE2A | |
| SCHEMBL15862452 | 0.59 | IL2 (0.58) | IL2NPY5RTP53 | |
| SCHEMBL22888249 | 0.58 | PDE10A (0.39) | NUDT1TP53 | |
| SCHEMBL13465854 | 0.57 | JAK2 (0.60) | JAK2JAK3PTK2DYRK1ADYRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021161084-A1 | N-(4-FLUOROPHENYL)-5-PHENYL-[1,2,4] TRIAZOLO [1,5-A] PYRIDINE-2-CARBOXAMIDE DERIVATIVES AND THEIR SYNTHESIS THEREOF | NINGEGOWDA RAGHU (IN) | 2021-08-19 | — | — | WO | disclosed |