Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL2 | P60568 | 2/20 | 0.52 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 3/20 | 0.44 |
| ▸ | JAK1 | P23458 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | TYK2 | P29597 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
| ▸ | SMO | Q99835 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.40 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.40 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.40 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23764113 | 0.80 | IL2 (0.39) | IL2NPY5RJAK2JAK1BRAF | |
| SCHEMBL23754207 | 0.78 | JAK1 (0.51) | JAK2JAK1TYK2SMN1; SMN2TP53 | |
| SCHEMBL23764043 | 0.77 | JAK1 (0.42) | JAK2JAK1SMN1; SMN2TP53IDO1 | |
| SCHEMBL23754392 | 0.76 | JAK2 (0.51) | JAK2JAK1TYK2SMN1; SMN2TP53 | |
| SCHEMBL23753737 | 0.76 | JAK1 (0.53) | JAK2JAK1TYK2SMN1; SMN2TP53 | |
| SCHEMBL23754203 | 0.73 | JAK2 (0.47) | JAK2JAK1TYK2SMN1; SMN2TP53 | |
| SCHEMBL23754239 | 0.73 | SMN1; SMN2 (0.46) | JAK1SMN1; SMN2TP53 | |
| SCHEMBL23754210 | 0.73 | MAPT (0.46) | JAK1USP2SMN1; SMN2TP53 | |
| SCHEMBL23764040 | 0.71 | JAK1 (0.48) | JAK2JAK1TYK2SMN1; SMN2TP53 | |
| SCHEMBL1827507 | 0.69 | IL2 (1.00) | IL2DDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021161084-A1 | N-(4-FLUOROPHENYL)-5-PHENYL-[1,2,4] TRIAZOLO [1,5-A] PYRIDINE-2-CARBOXAMIDE DERIVATIVES AND THEIR SYNTHESIS THEREOF | NINGEGOWDA RAGHU (IN) | 2021-08-19 | — | — | WO | disclosed |