Sugi Predict

Sugi Predict / Compounds / SCHEMBL2640360

SCHEMBL2640360

SCHEMBL2640360

COc1ccc(C(F)(F)F)cc1-c1cccc2nc(N)nn12

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ JAK2 O60674 5/20 0.56
▸ JAK3 P52333 5/20 0.56
▸ PTK2 Q05397 5/20 0.56
▸ JAK1 P23458 2/20 0.51
▸ NUDT1 P36639 4/20 0.49
▸ L3MBTL1 Q9Y468 2/20 0.43
▸ MAPT P10636 1/20 0.43
▸ NPSR1 Q6W5P4 1/20 0.43
▸ DYRK3 O43781 1/20 0.40
▸ CCNT1 O60563 1/20 0.40
▸ CCNA2 P20248 1/20 0.40
▸ CDK2 P24941 1/20 0.40
▸ CDK9 P50750 1/20 0.40
▸ CDK5 Q00535 1/20 0.40
▸ DYRK1A Q13627 1/20 0.40
▸ CDK5R1 Q15078 1/20 0.40
▸ DYRK2 Q92630 1/20 0.40
▸ DYRK1B Q9Y463 1/20 0.40
▸ EGLN2 Q96KS0 1/20 0.40
▸ RAB9A P51151 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2634343 0.86 JAK2 (0.56) JAK2JAK3PTK2JAK1L3MBTL1
SCHEMBL2635059 0.86 JAK2 (0.56) JAK2JAK3PTK2JAK1L3MBTL1
SCHEMBL12973788 0.81 JAK2 (0.60) JAK2JAK3PTK2JAK1EGLN2
SCHEMBL2634386 0.77 JAK2 (0.56) JAK2JAK3PTK2JAK1DYRK3
SCHEMBL14888861 0.76 JAK1 (0.66) JAK1NUDT1MAPTEGLN2RAB9A
SCHEMBL2640350 0.73 JAK2 (1.00) JAK2JAK3PTK2
SCHEMBL30263737 0.73 JAK1 (0.65) JAK2JAK3JAK1NUDT1EGLN2
Bicarbonate SCHEMBL3262534 0.72 NUDT1 (0.62) JAK2JAK1NUDT1DYRK3CCNT1
SCHEMBL12518501 0.72 NUDT1 (0.58) JAK3JAK1NUDT1EGLN2
SCHEMBL7150018 0.72 DYRK3 (0.47) JAK2JAK3NPSR1DYRK3CCNT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8633173-B2 Preparation and uses of 1,2,4-triazolo [1,5a] pyridine derivatives CEPHALON, INC (US) 2014-01-21 — — US disclosed
US-20130296312-A1 Preparation and Uses of 1,2,4-Triazolo [1,5a] Pyridine Derivatives CEPHALON, INC. 2013-11-07 — — US disclosed
US-8501936-B2 Preparation and uses of 1,2,4-triazolo [1,5a] pyridine derivatives CEPHALON, INC. (US) 2013-08-06 — — US disclosed
EP-2438066-A2 PREPARATION AND USES OF 1,2,4-TRIAZOLO [1,5a]PYRIDINE DERIVATIVES Cephalon, Inc. (US) 2012-04-11 — — EP disclosed
US-20100311693-A1 Preparation and Uses of 1,2,4-Triazolo [1,5a] Pyridine Derivatives CEPHALON, INC. (US) 2010-12-09 — — US disclosed
WO-2010141796-A2 PREPARATION AND USES OF 1,2,4-TRIAZOLO [1,5a] PYRIDINE DERIVATIVES CEPHALON, INC. (US) 2010-12-09 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130296312-A1 Preparation and Uses of 1,2,4-Triazolo [1,5a] Pyridine Derivatives JAK2, JAK1, JAK3 JAK2 1/4885JAK3 3/4885PTK2 451/4885
US-20100311693-A1 Preparation and Uses of 1,2,4-Triazolo [1,5a] Pyridine Derivatives CCNA1, CCNY, RB1 JAK2 31/4885JAK3 175/4885PTK2 1114/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.