Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 5/20 | 0.51 |
| ▸ | MKNK2 | Q9HBH9 | 4/20 | 0.51 |
| ▸ | DHODH | Q02127 | 3/20 | 0.46 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.46 |
| ▸ | MYC | P01106 | 1/20 | 0.45 |
| ▸ | ERN1 | O75460 | 1/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.44 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.43 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22367342 | 0.81 | MKNK1 (0.64) | MKNK1MKNK2DHODHAOC3ERN1 | |
| SCHEMBL2589651 | 0.80 | ERN1 (0.60) | MKNK1MKNK2DHODHERN1 | |
| SCHEMBL1565391 | 0.80 | PARP1 (0.55) | — | |
| SCHEMBL29551821 | 0.80 | PARP1 (0.55) | — | |
| SCHEMBL13412869 | 0.78 | NR4A2 (0.36) | MKNK1MKNK2DHODHAOC3ERN1 | |
| SCHEMBL13179896 | 0.77 | MAOA (0.44) | — | |
| SCHEMBL1788682 | 0.77 | HSD17B1 (0.65) | MKNK1MKNK2DHODHERN1 | |
| SCHEMBL3790217 | 0.77 | MAOA (0.57) | MKNK1MKNK2DHODHAOC3ERN1 | |
| SCHEMBL30958373 | 0.77 | HSD17B1 (0.65) | MKNK1MKNK2DHODHERN1 | |
| SCHEMBL15547657 | 0.75 | CHEK2 (0.67) | MKNK1MKNK2DHODHMAP4K4CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3865472-A1 | THROMBOXANE RECEPTOR ANTAGONISTS | ATXA Therapeutics Limited (IE) | 2021-08-18 | — | — | EP | disclosed |