Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.37 |
| ▸ | GRIN2A | Q12879 | 3/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.37 |
| ▸ | GBA1 | P04062 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.35 |
| ▸ | WNT1 | P04628 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | FLT4 | P35916 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23770341 | 0.97 | MAPT (0.38) | NAMPTMAPTGRIN1GRIN2AGRIN2B | |
| SCHEMBL23770320 | 0.89 | MAPT (0.47) | NAMPTMAPTCNR1CNR2HTT | |
| SCHEMBL23770319 | 0.83 | KMT2A (0.44) | NAMPTHTTROCK1 | |
| SCHEMBL23770384 | 0.82 | PRCP (0.42) | CNR1CNR2 | |
| SCHEMBL23770116 | 0.82 | PRCP (0.42) | CNR1CNR2 | |
| SCHEMBL23770336 | 0.81 | MAPT (0.36) | MAPTGBA1SMYD3WNT1DYRK1A | |
| SCHEMBL31659148 | 0.81 | CHRM4 (0.41) | MAPTWNT1DYRK1ANPC1LMNA | |
| SCHEMBL23770104 | 0.81 | CHRM4 (0.41) | MAPTWNT1DYRK1ANPC1LMNA | |
| SCHEMBL23770102 | 0.80 | RAB9A (0.47) | HTTSMN1; SMN2NPC1LMNARAB9A | |
| SCHEMBL26748895 | 0.79 | NAMPT (0.40) | NAMPTMAPTGBA1SMYD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11708353-B2 | Inhibitors of prolyl-tRNA-synthetase | THE GENERAL HOSPITAL CORPORATION (US) | 2023-07-25 | — | — | US | disclosed |
| US-11708353-B2 | Inhibitors of prolyl-tRNA-synthetase | THE GENERAL HOSPITAL CORPORATION (US) | 2023-07-25 | — | — | US | disclosed |
| US-20210253558-A1 | Inhibitors of Prolyl-tRNA-Synthetase | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2021-08-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11708353-B2 | Inhibitors of prolyl-tRNA-synthetase | GARS1, AARS1, NSUN3 | NAMPT 782/4885MAPT 2682/4885GRIN1 1489/4885 |
| US-20210253558-A1 | Inhibitors of Prolyl-tRNA-Synthetase | GARS1, AARS1, TRMT1 | NAMPT 454/4885MAPT 2250/4885GRIN1 1844/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.