Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.36 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 2/20 | 0.33 |
| ▸ | TACR1 | P25103 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 3/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | GBA1 | P04062 | 1/20 | 0.32 |
| ▸ | GALR2 | O43603 | 2/20 | 0.31 |
| ▸ | GALR1 | P47211 | 2/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23770664 | 0.99 | NPY5R (0.36) | PDE10ANPY5RKDM4ECYP1A2TDP1 | |
| SCHEMBL23770859 | 0.92 | CYP1A2 (0.44) | KDM4ECYP1A2TDP1CYP2C19ALDH1A1 | |
| SCHEMBL23770653 | 0.92 | CNR2 (0.40) | CYP1A2CYP2C19ALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL23770663 | 0.92 | CYP1A2 (0.43) | KDM4ECYP1A2TDP1CYP2C19ALDH1A1 | |
| SCHEMBL23770840 | 0.91 | KDM4E (0.35) | KDM4ECYP1A2TDP1CYP2C19ALDH1A1 | |
| SCHEMBL23770725 | 0.90 | CYP1A2 (0.37) | KDM4ECYP1A2TDP1CYP2C19ALDH1A1 | |
| SCHEMBL23770592 | 0.89 | ADORA2A (0.32) | — | |
| SCHEMBL23770647 | 0.89 | KDM4E (0.33) | PDE10AKDM4ECYP1A2TDP1CYP2C19 | |
| SCHEMBL23770452 | 0.88 | PDE10A (0.34) | PDE10ANPY5RKDM4ETDP1CNR2 | |
| SCHEMBL23770694 | 0.88 | GALR2 (0.40) | PDE10ANPY5RKDM4ECYP1A2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504194-B1 | N-(PYRIDIN-2-YL)PYRIDINE-SULFONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2021-08-18 | — | — | EP | disclosed |