Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
| ▸ | KIF18A | Q8NI77 | 2/20 | 0.31 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.30 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.30 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.30 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23770433 | 0.89 | PDE10A (0.36) | — | |
| SCHEMBL23770597 | 0.89 | RBP4 (0.33) | ADORA2AADORA1KIF18A | |
| SCHEMBL23770664 | 0.89 | NPY5R (0.36) | — | |
| SCHEMBL23770832 | 0.87 | RBP4 (0.33) | KIF18AGRIN2B | |
| SCHEMBL19970159 | 0.87 | AURKA (0.31) | — | |
| SCHEMBL23770863 | 0.86 | KHK (0.37) | — | |
| SCHEMBL19970221 | 0.86 | EPHX2 (0.31) | — | |
| SCHEMBL23770859 | 0.84 | CYP1A2 (0.44) | — | |
| SCHEMBL23770753 | 0.83 | GRIN2B (0.36) | GRIN2B | |
| SCHEMBL23770653 | 0.83 | CNR2 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504194-B1 | N-(PYRIDIN-2-YL)PYRIDINE-SULFONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2021-08-18 | — | — | EP | disclosed |