Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.39 |
| ▸ | CLK2 | P49760 | 1/20 | 0.39 |
| ▸ | GSK3A | P49840 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.39 |
| ▸ | STK3 | Q13188 | 1/20 | 0.39 |
| ▸ | HIPK4 | Q8NE63 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 5/20 | 0.36 |
| ▸ | RAF1 | P04049 | 4/20 | 0.36 |
| ▸ | ATR | Q13535 | 2/20 | 0.36 |
| ▸ | ATRIP | Q8WXE1 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23770433 | 0.92 | PDE10A (0.36) | CNR2ALDH1A1GAACYP1A2CYP3A4 | |
| SCHEMBL23770664 | 0.91 | NPY5R (0.36) | CNR2ALDH1A1MAPK1LMNAGAA | |
| SCHEMBL23770859 | 0.90 | CYP1A2 (0.44) | CNR2ALDH1A1MAPK1CYP1A2CYP3A4 | |
| SCHEMBL23770663 | 0.89 | CYP1A2 (0.43) | ALDH1A1CLK4CYP1A2CYP3A4TSHR | |
| SCHEMBL23770840 | 0.88 | KDM4E (0.35) | ALDH1A1MAPTLMNANPSR1CYP1A2 | |
| SCHEMBL23770725 | 0.87 | CYP1A2 (0.37) | ALDH1A1GSK3BCYP1A2CYP3A4ALOX15 | |
| SCHEMBL23770647 | 0.86 | KDM4E (0.33) | CNR2ALDH1A1MAPK1GAANPSR1 | |
| SCHEMBL23770723 | 0.86 | PTPN11 (0.35) | CNR2ALDH1A1MAPTLMNAGAA | |
| SCHEMBL23770753 | 0.85 | GRIN2B (0.36) | CLK2BRAFRAF1 | |
| SCHEMBL23770673 | 0.83 | HRH4 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504194-B1 | N-(PYRIDIN-2-YL)PYRIDINE-SULFONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2021-08-18 | — | — | EP | disclosed |