Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN2 | Q96KS0 | 3/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 2/20 | 0.37 |
| ▸ | NOS3 | P29474 | 1/20 | 0.36 |
| ▸ | NOS1 | P29475 | 1/20 | 0.36 |
| ▸ | NOS2 | P35228 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.35 |
| ▸ | CDK9 | P50750 | 1/20 | 0.35 |
| ▸ | FASN | P49327 | 3/20 | 0.35 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | CDC7 | O00311 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
| ▸ | EIF4E | P06730 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23770666 | 0.80 | KRAS (0.39) | EGLN2CYP11B1CYP11B2ARFASN | |
| SCHEMBL23770740 | 0.79 | HSD11B1 (0.33) | EGLN2ARABL1CDC7CDK2 | |
| SCHEMBL19925179 | 0.78 | HSD11B1 (0.46) | ABL1KDM4E | |
| SCHEMBL29464537 | 0.78 | HSD11B1 (0.46) | ABL1KDM4E | |
| SCHEMBL29464929 | 0.78 | ABL1 (0.46) | NOS3NOS1NOS2ABL1CCNT1 | |
| SCHEMBL19925120 | 0.78 | ABL1 (0.46) | NOS3NOS1NOS2ABL1CCNT1 | |
| SCHEMBL23770430 | 0.76 | ABL1 (0.33) | EGLN2CYP11B1CYP11B2ARABL1 | |
| SCHEMBL19951268 | 0.74 | SCN9A (0.45) | — | |
| SCHEMBL19968759 | 0.73 | BACE1 (0.47) | NOS3NOS1NOS2ADORA2AHPGD | |
| SCHEMBL29464888 | 0.73 | BACE1 (0.47) | NOS3NOS1NOS2ADORA2AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504194-B1 | N-(PYRIDIN-2-YL)PYRIDINE-SULFONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2021-08-18 | — | — | EP | disclosed |