Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 2/20 | 0.47 |
| ▸ | CTSD | P07339 | 1/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.46 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.42 |
| ▸ | DPP4 | P27487 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | NOS3 | P29474 | 1/20 | 0.39 |
| ▸ | NOS1 | P29475 | 1/20 | 0.39 |
| ▸ | NOS2 | P35228 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | EPHA4 | P54764 | 1/20 | 0.38 |
| ▸ | HEXA | P06865 | 1/20 | 0.37 |
| ▸ | HEXB | P07686 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19968759 | 1.00 | BACE1 (0.47) | BACE1CTSDADORA2APLA2G7DPP4 | |
| SCHEMBL19968794 | 0.81 | NOS3 (0.42) | BACE1CTSDNOS3NOS1NOS2 | |
| SCHEMBL19925120 | 0.77 | ABL1 (0.46) | BACE1CTSDPLA2G7NOS3NOS1 | |
| SCHEMBL29464929 | 0.77 | ABL1 (0.46) | BACE1CTSDPLA2G7NOS3NOS1 | |
| SCHEMBL23770590 | 0.77 | ADORA2A (0.35) | BACE1CTSDADORA2APLA2G7DPP4 | |
| SCHEMBL19968754 | 0.75 | HSD11B1 (0.38) | BACE1CTSDADORA2ALMNAHPGD | |
| SCHEMBL19968786 | 0.75 | BACE1 (0.44) | BACE1CTSDADORA2ADPP4LMNA | |
| SCHEMBL23770688 | 0.74 | DPP4 (0.33) | BACE1CTSDADORA2ADPP4 | |
| SCHEMBL23770777 | 0.74 | ADORA2A (0.33) | BACE1CTSDADORA2ADPP4EPHA4 | |
| SCHEMBL29464947 | 0.74 | NPC1 (0.41) | BACE1DPP4LMNAMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109641873-B | N- (pyridin-2-yl) pyridine-sulfonamide derivatives and their use for the treatment of disease | 诺华股份有限公司 | 2022-03-18 | — | — | CN | disclosed |