Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.33 |
| ▸ | AR | P10275 | 2/20 | 0.32 |
| ▸ | CDC7 | O00311 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.31 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.30 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23770611 | 0.93 | EGLN2 (0.36) | HSD11B1ARCDC7CDK2MAP4K1 | |
| SCHEMBL23770652 | 0.85 | HSD11B1 (0.32) | HSD11B1ARCDC7CDK2 | |
| SCHEMBL23770558 | 0.85 | AGPAT2 (0.40) | ABL1 | |
| SCHEMBL23770590 | 0.84 | ADORA2A (0.35) | — | |
| SCHEMBL23770707 | 0.82 | AGPAT2 (0.39) | ABL1 | |
| SCHEMBL23770528 | 0.82 | ADORA2A (0.35) | LRRK2 | |
| SCHEMBL23770430 | 0.81 | ABL1 (0.33) | ARCDC7CDK2ABL1MAP4K1 | |
| SCHEMBL23770555 | 0.80 | ADORA2A (0.32) | — | |
| SCHEMBL23770602 | 0.79 | NOS3 (0.33) | — | |
| SCHEMBL19925179 | 0.79 | HSD11B1 (0.46) | HSD11B1ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504194-B1 | N-(PYRIDIN-2-YL)PYRIDINE-SULFONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2021-08-18 | — | — | EP | disclosed |