Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | GBA1 | P04062 | 1/20 | 0.33 |
| ▸ | TACR1 | P25103 | 2/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | KRAS | P01116 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SCD | O00767 | 7/20 | 0.32 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.32 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23770448 | 0.87 | CKS1B (0.40) | LMNAMAPT | |
| SCHEMBL23770787 | 0.86 | PDE10A (0.35) | LMNAALDH1A1GBA1TACR1KDM4E | |
| SCHEMBL23770621 | 0.85 | PDE10A (0.35) | LMNAALDH1A1GBA1TACR1KDM4E | |
| SCHEMBL23770712 | 0.85 | NPC1 (0.33) | ALDH1A1POLBKDM4E | |
| SCHEMBL23770748 | 0.83 | RORC (0.33) | TACR1P2RX7 | |
| SCHEMBL23770416 | 0.83 | PTPN11 (0.37) | — | |
| SCHEMBL19968844 | 0.82 | SMN1; SMN2 (0.35) | LMNASMN1; SMN2ALDH1A1POLBMAPT | |
| SCHEMBL29464397 | 0.82 | SMN1; SMN2 (0.35) | LMNASMN1; SMN2ALDH1A1POLBMAPT | |
| SCHEMBL23770735 | 0.81 | — | — | |
| Hydrochloric Acid SCHEMBL19925388 | 0.81 | SMN1; SMN2 (0.34) | LMNASMN1; SMN2ALDH1A1POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504194-B1 | N-(PYRIDIN-2-YL)PYRIDINE-SULFONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2021-08-18 | — | — | EP | disclosed |