Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23770787 | 0.88 | PDE10A (0.35) | KDM4EALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL23770621 | 0.87 | PDE10A (0.35) | MEN1KMT2AKDM4EALDH1A1CYP1A2 | |
| SCHEMBL23770464 | 0.85 | LMNA (0.34) | POLBKDM4EALDH1A1 | |
| SCHEMBL23770416 | 0.83 | PTPN11 (0.37) | — | |
| SCHEMBL23770448 | 0.83 | CKS1B (0.40) | — | |
| SCHEMBL23770649 | 0.81 | PIM1 (0.34) | MEN1KMT2ACYP1A2CYP2D6TSHR | |
| SCHEMBL23770480 | 0.81 | GRIN2B (0.33) | — | |
| SCHEMBL23770748 | 0.81 | RORC (0.33) | — | |
| SCHEMBL29464471 | 0.80 | SCN1A (0.35) | NPC1LPAR2MEN1POLBKMT2A | |
| SCHEMBL19968839 | 0.80 | SCN1A (0.35) | NPC1LPAR2MEN1POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504194-B1 | N-(PYRIDIN-2-YL)PYRIDINE-SULFONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2021-08-18 | — | — | EP | disclosed |