Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CTSD | P07339 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.32 |
| ▸ | FEN1 | P39748 | 1/20 | 0.32 |
| ▸ | EPHA4 | P54764 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23770571 | 0.90 | NOS3 (0.33) | NOS3NOS2 | |
| SCHEMBL23770575 | 0.89 | ADORA2A (0.37) | ADORA2ACTSDBACE1ALDH1A1CYP1A2 | |
| SCHEMBL23770600 | 0.86 | ALOX5AP (0.35) | ALOX5APFEN1 | |
| SCHEMBL23770590 | 0.85 | ADORA2A (0.35) | ADORA2ACTSDBACE1EPHA4DPP4 | |
| SCHEMBL23770676 | 0.85 | ADORA2A (0.35) | ADORA2ACTSDBACE1ALDH1A1EPHA4 | |
| SCHEMBL23770551 | 0.85 | PTPN1 (0.36) | ADORA2ACTSDBACE1ALDH1A1CYP1A2 | |
| SCHEMBL23770584 | 0.82 | GABRA1 (0.34) | ADORA2ACTSDBACE1EPHA4DPP4 | |
| SCHEMBL23770417 | 0.80 | GAA (0.33) | GAA | |
| SCHEMBL23770633 | 0.80 | PLA2G7 (0.36) | MAPTBACE1ALDH1A1EPHA4DPP4 | |
| SCHEMBL23770415 | 0.80 | ADORA2A (0.34) | ADORA2ASMN1; SMN2TP53MAPTBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504194-B1 | N-(PYRIDIN-2-YL)PYRIDINE-SULFONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2021-08-18 | — | — | EP | disclosed |