Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.32 |
| ▸ | ABL1 | P00519 | 2/20 | 0.32 |
| ▸ | BCR | P11274 | 2/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23770566 | 0.86 | AGPAT2 (0.35) | SCN9AABL1 | |
| SCHEMBL23770551 | 0.85 | PTPN1 (0.36) | — | |
| SCHEMBL23770652 | 0.83 | HSD11B1 (0.32) | — | |
| SCHEMBL23770405 | 0.81 | PTPN1 (0.31) | — | |
| SCHEMBL29464546 | 0.80 | SCN9A (0.40) | SCN9AABL1CHRM5 | |
| SCHEMBL19968782 | 0.80 | SCN9A (0.40) | SCN9AABL1CHRM5 | |
| SCHEMBL23770610 | 0.78 | BACE1 (0.38) | — | |
| SCHEMBL23770752 | 0.78 | MPL (0.34) | — | |
| SCHEMBL23770399 | 0.76 | PTPN1 (0.35) | — | |
| SCHEMBL23770569 | 0.76 | EPAS1 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504194-B1 | N-(PYRIDIN-2-YL)PYRIDINE-SULFONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2021-08-18 | — | — | EP | disclosed |