Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGPAT2 | O15120 | 2/20 | 0.35 |
| ▸ | EPHA4 | P54764 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 4/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.31 |
| ▸ | MPL | P40238 | 1/20 | 0.31 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.31 |
| ▸ | KRAS | P01116 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23770551 | 0.88 | PTPN1 (0.36) | EPHA4PTPN1MPLTRPA1 | |
| SCHEMBL23770604 | 0.86 | DHFR (0.32) | ABL1SCN9A | |
| SCHEMBL23770652 | 0.86 | HSD11B1 (0.32) | TRPA1 | |
| SCHEMBL23770558 | 0.85 | AGPAT2 (0.40) | AGPAT2EPHA4ABL1 | |
| SCHEMBL23770405 | 0.84 | PTPN1 (0.31) | PTPN1MPL | |
| SCHEMBL23770752 | 0.83 | MPL (0.34) | PTPN1MPL | |
| SCHEMBL23770452 | 0.82 | PDE10A (0.34) | ABL1 | |
| SCHEMBL23770610 | 0.82 | BACE1 (0.38) | PTPN1MPL | |
| SCHEMBL23770466 | 0.81 | CYP1A2 (0.37) | ABL1 | |
| SCHEMBL23770773 | 0.81 | ABL1 (0.37) | AGPAT2EPHA4ABL1TRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504194-B1 | N-(PYRIDIN-2-YL)PYRIDINE-SULFONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2021-08-18 | — | — | EP | disclosed |