Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.32 |
| ▸ | MPL | P40238 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 2/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.30 |
| ▸ | DPP4 | P27487 | 1/20 | 0.30 |
| ▸ | CTSD | P07339 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23770823 | 0.87 | CYP1A2 (0.38) | PTPN1 | |
| SCHEMBL23770787 | 0.82 | PDE10A (0.35) | — | |
| SCHEMBL23770621 | 0.81 | PDE10A (0.35) | — | |
| SCHEMBL23770416 | 0.80 | PTPN11 (0.37) | — | |
| SCHEMBL23770649 | 0.79 | PIM1 (0.34) | DPP4 | |
| SCHEMBL23770480 | 0.79 | GRIN2B (0.33) | — | |
| SCHEMBL23770551 | 0.77 | PTPN1 (0.36) | PTPN1MPLADORA2ABACE1DPP4 | |
| SCHEMBL23770712 | 0.77 | NPC1 (0.33) | — | |
| SCHEMBL23770413 | 0.77 | CCNT1 (0.47) | — | |
| SCHEMBL19968786 | 0.76 | BACE1 (0.44) | PTPN1MPLADORA2ABACE1HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504194-B1 | N-(PYRIDIN-2-YL)PYRIDINE-SULFONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2021-08-18 | — | — | EP | disclosed |