Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 6/20 | 0.34 |
| ▸ | PIM2 | Q9P1W9 | 5/20 | 0.34 |
| ▸ | PIM3 | Q86V86 | 4/20 | 0.34 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.33 |
| ▸ | DPP4 | P27487 | 2/20 | 0.32 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.32 |
| ▸ | CTSS | P25774 | 1/20 | 0.31 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.31 |
| ▸ | TTR | P02766 | 1/20 | 0.31 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | HTR3B | O95264 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23770787 | 0.87 | PDE10A (0.35) | CYP1A2CYP2D6TSHR | |
| SCHEMBL23770621 | 0.86 | PDE10A (0.35) | MEN1CYP1A2CYP2D6TSHRKMT2A | |
| SCHEMBL23770416 | 0.84 | PTPN11 (0.37) | PTPN11PRKCQ | |
| SCHEMBL23770766 | 0.83 | PRKCQ (0.35) | PIM1PIM2PIM3PRKCQCYP1A2 | |
| SCHEMBL23770662 | 0.82 | GRIN2B (0.31) | — | |
| SCHEMBL23770634 | 0.82 | CYP1A2 (0.34) | CYP1A2 | |
| SCHEMBL23770480 | 0.81 | GRIN2B (0.33) | — | |
| SCHEMBL23770712 | 0.81 | NPC1 (0.33) | MEN1CYP1A2CYP2D6TSHRKMT2A | |
| SCHEMBL23770464 | 0.81 | LMNA (0.34) | — | |
| SCHEMBL19925084 | 0.80 | CTSS (0.36) | PTPN11SYKHRH4HRH3DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504194-B1 | N-(PYRIDIN-2-YL)PYRIDINE-SULFONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2021-08-18 | — | — | EP | disclosed |