Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 3/20 | 0.36 |
| ▸ | MPL | P40238 | 1/20 | 0.33 |
| ▸ | RBP4 | P02753 | 1/20 | 0.33 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.32 |
| ▸ | PRKCA | P17252 | 1/20 | 0.32 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.32 |
| ▸ | CLK2 | P49760 | 1/20 | 0.31 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.31 |
| ▸ | RAF1 | P04049 | 3/20 | 0.31 |
| ▸ | BRAF | P15056 | 3/20 | 0.31 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23770806 | 0.90 | RBP4 (0.36) | GRIN2BMPLRBP4 | |
| SCHEMBL23770836 | 0.89 | MPL (0.33) | MPLSOS1PRKCAPRKCQCLK2 | |
| SCHEMBL23770822 | 0.89 | MPL (0.33) | GRIN2BMPLPRKCAPRKCQCLK2 | |
| SCHEMBL23770810 | 0.88 | MPL (0.32) | GRIN2BMPLRBP4PRKCAPRKCQ | |
| SCHEMBL23770433 | 0.88 | PDE10A (0.36) | PDE10A | |
| SCHEMBL23770664 | 0.87 | NPY5R (0.36) | PDE10A | |
| SCHEMBL23770840 | 0.86 | KDM4E (0.35) | GRIN2B | |
| SCHEMBL23770859 | 0.86 | CYP1A2 (0.44) | — | |
| SCHEMBL23770725 | 0.85 | CYP1A2 (0.37) | PRKCAPRKCQ | |
| SCHEMBL23770663 | 0.85 | CYP1A2 (0.43) | SOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504194-B1 | N-(PYRIDIN-2-YL)PYRIDINE-SULFONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2021-08-18 | — | — | EP | disclosed |