Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GALR2 | O43603 | 1/20 | 0.36 |
| ▸ | GALR1 | P47211 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.35 |
| ▸ | CAMK1D | Q8IU85 | 1/20 | 0.35 |
| ▸ | SCN1A | P35498 | 4/20 | 0.33 |
| ▸ | SCN8A | Q9UQD0 | 4/20 | 0.33 |
| ▸ | POLB | P06746 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19968888 | 1.00 | GALR2 (0.36) | GALR2GALR1KMT2AHTTLMNA | |
| SCHEMBL19951444 | 0.91 | ITGB2 (0.41) | KMT2ACAMK1DPROKR1 | |
| SCHEMBL19951445 | 0.91 | ITGB2 (0.41) | KMT2ACAMK1DPROKR1 | |
| SCHEMBL29464504 | 0.91 | ITGB2 (0.41) | KMT2ACAMK1DPROKR1 | |
| SCHEMBL19968885 | 0.89 | HSD11B1 (0.40) | KMT2AHTTLMNAMAPTMEN1 | |
| SCHEMBL19925068 | 0.88 | ROS1 (0.33) | LMNAMAPTHSD17B10SCN1ASCN8A | |
| SCHEMBL19968894 | 0.87 | GALR2 (0.38) | GALR2GALR1LMNAMAPTALDH1A1 | |
| SCHEMBL19968902 | 0.87 | GALR2 (0.38) | GALR2GALR1LMNAMAPTALDH1A1 | |
| SCHEMBL19925629 | 0.86 | ADRB2 (0.39) | ALDH1A1HSD17B10 | |
| Hydrochloric Acid SCHEMBL19925392 | 0.86 | ADRB2 (0.40) | ALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504194-B1 | N-(PYRIDIN-2-YL)PYRIDINE-SULFONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2021-08-18 | — | — | EP | disclosed |