Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GALR2 | O43603 | 1/20 | 0.38 |
| ▸ | GALR1 | P47211 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | RBP4 | P02753 | 4/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | AXL | P30530 | 1/20 | 0.34 |
| ▸ | UTS2R | Q9UKP6 | 2/20 | 0.34 |
| ▸ | ALPL | P05186 | 2/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | SCN1A | P35498 | 2/20 | 0.34 |
| ▸ | SCN8A | Q9UQD0 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19968894 | 1.00 | GALR2 (0.38) | GALR2GALR1ALDH1A1MAPTLMNA | |
| SCHEMBL19968895 | 0.92 | HMOX1 (0.37) | GALR2GALR1ALDH1A1MAPTLMNA | |
| SCHEMBL19968892 | 0.91 | TP53 (0.38) | MAPTHTR6RBP4TP53SCN9A | |
| SCHEMBL23770670 | 0.87 | GALR2 (0.36) | GALR2GALR1ALDH1A1MAPTLMNA | |
| SCHEMBL19968888 | 0.87 | GALR2 (0.36) | GALR2GALR1ALDH1A1MAPTLMNA | |
| SCHEMBL19968885 | 0.85 | HSD11B1 (0.40) | ALDH1A1MAPTLMNAPOLBMAPK1 | |
| SCHEMBL19927799 | 0.83 | RBP4 (0.36) | HTR6RBP4TP53SCN9ACNR1 | |
| SCHEMBL19951333 | 0.83 | RBP4 (0.36) | HTR6RBP4TP53SCN9ACNR1 | |
| SCHEMBL19968890 | 0.83 | HMOX1 (0.37) | ALDH1A1MAPTLMNAMAPK1RBP4 | |
| SCHEMBL19951381 | 0.83 | RBP4 (0.36) | ALDH1A1MAPTHTR6RBP4TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180072673-A1 | N-(pyridin-2-yl)pyridine-sulfonamide Derivatives and their Use in the Treatment of Disease | NOVARTIS AG (CH) | 2018-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180072673-A1 | N-(pyridin-2-yl)pyridine-sulfonamide Derivatives and their Use in the Treatment of Disease | CFTR, P2RY1, P2RX5 | GALR2 2904/4885GALR1 3207/4885ALDH1A1 1455/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.