Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 1/20 | 0.35 |
| ▸ | KRAS | P01116 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 2/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22338280 | 0.88 | TRPA1 (0.36) | TRPA1HTR2C | |
| SCHEMBL23770610 | 0.87 | BACE1 (0.38) | BACE1 | |
| SCHEMBL23770551 | 0.85 | PTPN1 (0.36) | TRPA1BACE1 | |
| SCHEMBL23770609 | 0.84 | CCNT1 (0.32) | — | |
| SCHEMBL23770569 | 0.84 | EPAS1 (0.34) | TRPA1BACE1 | |
| SCHEMBL23770810 | 0.82 | MPL (0.32) | TRPA1 | |
| SCHEMBL23770761 | 0.81 | TRPA1 (0.34) | TRPA1BACE1 | |
| SCHEMBL23770628 | 0.81 | CYP1A2 (0.42) | TRPA1HTR2C | |
| SCHEMBL23770584 | 0.81 | GABRA1 (0.34) | BACE1 | |
| SCHEMBL23770752 | 0.80 | MPL (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504194-B1 | N-(PYRIDIN-2-YL)PYRIDINE-SULFONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2021-08-18 | — | — | EP | disclosed |