Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPL | P40238 | 1/20 | 0.32 |
| ▸ | RBP4 | P02753 | 5/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.32 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.32 |
| ▸ | CCNK | O75909 | 1/20 | 0.32 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | CDK9 | P50750 | 1/20 | 0.32 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.32 |
| ▸ | PRKCA | P17252 | 1/20 | 0.30 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.30 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23770822 | 0.88 | MPL (0.33) | MPLPDE10ACCNT1PRKCAPRKCQ | |
| SCHEMBL23770753 | 0.88 | GRIN2B (0.36) | MPLRBP4PDE10APRKCAPRKCQ | |
| SCHEMBL23770628 | 0.86 | CYP1A2 (0.42) | RBP4TRPA1CCNT1CCNKCCNE1 | |
| SCHEMBL23770686 | 0.85 | RBP4 (0.35) | RBP4PDE10ATRPA1 | |
| SCHEMBL23770665 | 0.85 | TLR7 (0.36) | — | |
| SCHEMBL23770836 | 0.85 | MPL (0.33) | MPLPRKCAPRKCQ | |
| SCHEMBL23770635 | 0.84 | IDH2 (0.39) | MPLRBP4 | |
| SCHEMBL23770597 | 0.84 | RBP4 (0.33) | RBP4TRPA1PRKCAPRKCQ | |
| SCHEMBL22338280 | 0.83 | TRPA1 (0.36) | TRPA1 | |
| SCHEMBL19970126 | 0.82 | IDH2 (0.39) | MPLRBP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504194-B1 | N-(PYRIDIN-2-YL)PYRIDINE-SULFONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2021-08-18 | — | — | EP | disclosed |