Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RBP4 | P02753 | 2/20 | 0.35 |
| ▸ | CNR2 | P34972 | 2/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.31 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.30 |
| ▸ | SYK | P43405 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23770628 | 0.88 | CYP1A2 (0.42) | RBP4CYP1A2CYP2C9KDM4EALDH1A1 | |
| SCHEMBL23770665 | 0.87 | TLR7 (0.36) | KDM4EALDH1A1HSD17B10SYK | |
| SCHEMBL19970126 | 0.87 | IDH2 (0.39) | RBP4HSD11B1SYK | |
| SCHEMBL19970141 | 0.87 | IDH2 (0.39) | RBP4HSD11B1SYK | |
| SCHEMBL23770456 | 0.87 | IDH2 (0.39) | RBP4HSD11B1SYK | |
| SCHEMBL23770801 | 0.86 | GPBAR1 (0.33) | RBP4HSD11B1 | |
| SCHEMBL23770664 | 0.86 | NPY5R (0.36) | CNR2PDE10ACYP1A2CYP2C9KDM4E | |
| SCHEMBL23770597 | 0.86 | RBP4 (0.33) | RBP4TRPA1SYK | |
| SCHEMBL23770810 | 0.85 | MPL (0.32) | RBP4PDE10ATRPA1 | |
| SCHEMBL23770433 | 0.85 | PDE10A (0.36) | CNR2PDE10ACYP1A2CYP2C9KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504194-B1 | N-(PYRIDIN-2-YL)PYRIDINE-SULFONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2021-08-18 | — | — | EP | disclosed |