Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 3/20 | 0.32 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.32 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.32 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.32 |
| ▸ | CLK2 | P49760 | 1/20 | 0.30 |
| ▸ | GSK3A | P49840 | 1/20 | 0.30 |
| ▸ | GSK3B | P49841 | 1/20 | 0.30 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.30 |
| ▸ | STK3 | Q13188 | 1/20 | 0.30 |
| ▸ | HIPK4 | Q8NE63 | 1/20 | 0.30 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.30 |
| ▸ | TTR | P02766 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.30 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23770698 | 0.91 | EPHX2 (0.31) | CACNA1CSCN5AEPHX2 | |
| SCHEMBL23770730 | 0.86 | RORC (0.32) | CACNA1CSCN5ACYP2C9EPHX2 | |
| SCHEMBL19970137 | 0.84 | BTK (0.34) | EPHX2 | |
| SCHEMBL19970208 | 0.84 | BTK (0.34) | EPHX2 | |
| SCHEMBL19925019 | 0.84 | AURKA (0.34) | AURKAAURKBCACNA1CSCN5A | |
| SCHEMBL29464905 | 0.84 | AURKA (0.34) | AURKAAURKBCACNA1CSCN5A | |
| SCHEMBL19970221 | 0.84 | EPHX2 (0.31) | AURKAAURKBEPHX2 | |
| SCHEMBL23770746 | 0.84 | RORC (0.33) | CLK2GSK3AGSK3BCSNK2A1STK3 | |
| SCHEMBL19970084 | 0.81 | BTK (0.33) | EPHX2 | |
| SCHEMBL19970085 | 0.81 | BTK (0.33) | EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504194-B1 | N-(PYRIDIN-2-YL)PYRIDINE-SULFONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2021-08-18 | — | — | EP | disclosed |