Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | CLK2 | P49760 | 1/20 | 0.33 |
| ▸ | GSK3A | P49840 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.33 |
| ▸ | STK3 | Q13188 | 1/20 | 0.33 |
| ▸ | HIPK4 | Q8NE63 | 1/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.33 |
| ▸ | KIF18A | Q8NI77 | 10/20 | 0.32 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.31 |
| ▸ | ACACB | O00763 | 1/20 | 0.31 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.31 |
| ▸ | PRKCA | P17252 | 1/20 | 0.30 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.30 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.30 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23770730 | 0.88 | RORC (0.32) | RORCCYP2C9EPHX2GPBAR1PRKCA | |
| SCHEMBL19970208 | 0.85 | BTK (0.34) | EPHX2KIF18A | |
| SCHEMBL19970137 | 0.85 | BTK (0.34) | EPHX2KIF18A | |
| SCHEMBL23770709 | 0.84 | AURKA (0.32) | CLK2GSK3AGSK3BCSNK2A1STK3 | |
| SCHEMBL19925432 | 0.83 | SCN1A (0.34) | RORCCLK2GSK3AGSK3BCSNK2A1 | |
| SCHEMBL29464543 | 0.83 | SCN1A (0.34) | RORCCLK2GSK3AGSK3BCSNK2A1 | |
| SCHEMBL23770654 | 0.83 | RORC (0.40) | RORCGPBAR1PTPN11 | |
| SCHEMBL23770572 | 0.83 | FFAR4 (0.35) | CYP2C9EPHX2GPBAR1PRKCAPRKCQ | |
| SCHEMBL23770801 | 0.81 | GPBAR1 (0.33) | RORCKIF18AGPBAR1ACACBPRKCA | |
| SCHEMBL23770721 | 0.81 | GPBAR1 (0.33) | RORCGPBAR1ACACBPRKCAPRKCQ |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504194-B1 | N-(PYRIDIN-2-YL)PYRIDINE-SULFONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2021-08-18 | — | — | EP | disclosed |