Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KHK | P50053 | 1/20 | 0.35 |
| ▸ | RBP4 | P02753 | 2/20 | 0.33 |
| ▸ | TTR | P02766 | 1/20 | 0.33 |
| ▸ | MPL | P40238 | 2/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.31 |
| ▸ | TACR1 | P25103 | 2/20 | 0.31 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.30 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.30 |
| ▸ | RORC | P51449 | 1/20 | 0.30 |
| ▸ | KIF18A | Q8NI77 | 6/20 | 0.30 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23770806 | 0.89 | RBP4 (0.36) | RBP4TTRMPLGRIN2BRORC | |
| SCHEMBL23770608 | 0.87 | NOTUM (0.41) | TTRMPLRORC | |
| SCHEMBL23770825 | 0.86 | KHK (0.40) | KHKRBP4TTRGRIN2B | |
| SCHEMBL23770488 | 0.85 | ITGB2 (0.40) | TTRMPLHSD11B1MEN1KMT2A | |
| SCHEMBL23770832 | 0.84 | RBP4 (0.33) | RBP4TTRGRIN2BPTPN11RORC | |
| SCHEMBL19925206 | 0.84 | KHK (0.36) | KHKRBP4TTRMPLKIF18A | |
| SCHEMBL23770863 | 0.84 | KHK (0.37) | KHK | |
| SCHEMBL23770433 | 0.83 | PDE10A (0.36) | TACR1CYP2C9MEN1KMT2A | |
| SCHEMBL23770723 | 0.83 | PTPN11 (0.35) | TACR1PTPN11 | |
| SCHEMBL23770664 | 0.83 | NPY5R (0.36) | TACR1CYP2C9MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504194-B1 | N-(PYRIDIN-2-YL)PYRIDINE-SULFONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2021-08-18 | — | — | EP | disclosed |