Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMO | Q99835 | 2/20 | 0.31 |
| ▸ | PTPN11 | Q06124 | 5/20 | 0.30 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.30 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.30 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.30 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.30 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.30 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.30 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.30 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.30 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.30 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23770800 | 0.91 | RORC (0.32) | SMOPTPN11HDAC3HDAC4HDAC1 | |
| SCHEMBL23770659 | 0.86 | PTPN11 (0.36) | SMOPTPN11HDAC3HDAC4HDAC1 | |
| SCHEMBL23770844 | 0.86 | PTPN11 (0.33) | SMOPTPN11HDAC3HDAC4HDAC1 | |
| SCHEMBL23770829 | 0.86 | HDAC3 (0.33) | SMOPTPN11HDAC3HDAC4HDAC1 | |
| SCHEMBL23770785 | 0.83 | LMNA (0.43) | SMO | |
| SCHEMBL23770837 | 0.83 | SMO (0.34) | SMO | |
| SCHEMBL29464492 | 0.82 | SMO (0.34) | SMOPTPN11 | |
| SCHEMBL19925793 | 0.82 | SMO (0.34) | SMOPTPN11 | |
| SCHEMBL23770843 | 0.81 | SMO (0.33) | SMOPTPN11HDAC3HDAC4HDAC1 | |
| SCHEMBL23770509 | 0.81 | CNR1 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504194-B1 | N-(PYRIDIN-2-YL)PYRIDINE-SULFONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2021-08-18 | — | — | EP | disclosed |