Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMO | Q99835 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | HTR3E | A5X5Y0 | 4/20 | 0.33 |
| ▸ | HTR3B | O95264 | 4/20 | 0.33 |
| ▸ | HTR3A | P46098 | 4/20 | 0.33 |
| ▸ | HTR3D | Q70Z44 | 4/20 | 0.33 |
| ▸ | HTR3C | Q8WXA8 | 4/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 4/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23770450 | 0.91 | HTR3E (0.43) | SMOKDM4EHTR3EHTR3BHTR3A | |
| SCHEMBL23770800 | 0.85 | RORC (0.32) | SMOKMT2ACNR1CNR2MEN1 | |
| SCHEMBL23770659 | 0.85 | PTPN11 (0.36) | SMOCNR1CNR2 | |
| SCHEMBL23770844 | 0.85 | PTPN11 (0.33) | SMOCNR1CNR2 | |
| SCHEMBL23770648 | 0.84 | GPBAR1 (0.41) | KDM4EKMT2AMEN1TSHRALDH1A1 | |
| SCHEMBL23770785 | 0.84 | LMNA (0.43) | SMOKDM4EL3MBTL1KMT2ATDP1 | |
| SCHEMBL19970116 | 0.84 | DGAT1 (0.35) | CNR1CNR2 | |
| SCHEMBL23770475 | 0.83 | L3MBTL1 (0.39) | KDM4EL3MBTL1KMT2ACNR1CNR2 | |
| SCHEMBL23770843 | 0.83 | SMO (0.33) | SMO | |
| SCHEMBL23770874 | 0.83 | SMO (0.31) | SMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504194-B1 | N-(PYRIDIN-2-YL)PYRIDINE-SULFONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2021-08-18 | — | — | EP | disclosed |