Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.58 |
| ▸ | NAMPT | P43490 | 3/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.49 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.49 |
| ▸ | XBP1 | P17861 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.48 |
| ▸ | SDCBP | O00560 | 1/20 | 0.48 |
| ▸ | SDC2 | P34741 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22291745 | 0.85 | EPHX2 (0.64) | NAMPTHDAC1L3MBTL1NR1H4HDAC6 | |
| SCHEMBL2507542 | 0.85 | NAMPT (0.60) | NAMPTHDAC1L3MBTL1NR1H4HDAC6 | |
| SCHEMBL6395877 | 0.85 | NAMPT (0.50) | ALDH1A1LMNACYP1A2ALOX15CYP2C19 | |
| SCHEMBL3180689 | 0.84 | L3MBTL1 (0.61) | NAMPTHDAC1L3MBTL1MAPTNPSR1 | |
| SCHEMBL2588001 | 0.84 | SDCBP (0.50) | ALDH1A1NAMPTHDAC1L3MBTL1MAPT | |
| SCHEMBL6622954 | 0.84 | NAMPT (0.59) | LMNACYP1A2CYP2C19NAMPTHDAC1 | |
| SCHEMBL4815641 | 0.83 | NAMPT (0.51) | NAMPTHDAC1L3MBTL1MAPTNPSR1 | |
| SCHEMBL21341006 | 0.83 | NAMPT (0.52) | NAMPTHDAC1L3MBTL1MAPTNPSR1 | |
| SCHEMBL23899245 | 0.83 | NAMPT (0.72) | LMNANAMPTHDAC1L3MBTL1MAPT | |
| SCHEMBL5736115 | 0.83 | HDAC1 (0.60) | LMNACYP1A2CYP2C19NAMPTHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12606520-B2 | Calpain-2 inhibitor compounds and methods of treatment | WESTERN UNIVERSITY OF HEALTH SCIENCES (US) | 2026-04-21 | — | — | US | disclosed |
| US-20230091121-A1 | CALPAIN-2 INHIBITOR COMPOUNDS AND METHODS OF TREATMENT | UNITED STATES GOVERNMENT | 2023-03-23 | — | — | US | disclosed |
| WO-2022192162-A1 | NOVEL HETEROAROMATIC COMPOUNDS EXHIBITING ANTIFUNGAL ACTIVITY AND THEIR METHOD OF USE | FOX CHASE CHEMICAL DIVERSITY CENTER, INC. (US) | 2022-09-15 | — | — | WO | disclosed |
| WO-2021163631-A1 | CALPAIN-2 INHIBITOR COMPOUNDS AND METHODS OF TREATMENT | WESTERN UNIVERSITY OF HEALTH SCIENCES (US) | 2021-08-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230091121-A1 | CALPAIN-2 INHIBITOR COMPOUNDS AND METHODS OF TREATMENT | CAPN2, CAPNS1, CAPN1 | ALDH1A1 3467/4885LMNA 940/4885CYP1A2 3822/4885 |
| US-12606520-B2 | Calpain-2 inhibitor compounds and methods of treatment | CAPN2, CAPN1, CAPNS1 | ALDH1A1 3630/4885LMNA 1021/4885CYP1A2 3243/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.