Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 13/20 | 0.72 |
| ▸ | KCNH2 | Q12809 | 9/20 | 0.62 |
| ▸ | SCN5A | Q14524 | 9/20 | 0.62 |
| ▸ | SYK | P43405 | 1/20 | 0.53 |
| ▸ | PLK4 | O00444 | 1/20 | 0.53 |
| ▸ | AURKA | O14965 | 2/20 | 0.52 |
| ▸ | CDK1 | P06493 | 1/20 | 0.52 |
| ▸ | CDK4 | P11802 | 1/20 | 0.52 |
| ▸ | CDK2 | P24941 | 1/20 | 0.52 |
| ▸ | CDK7 | P50613 | 1/20 | 0.52 |
| ▸ | CDK9 | P50750 | 1/20 | 0.52 |
| ▸ | IKBKB | O14920 | 1/20 | 0.52 |
| ▸ | RAD52 | P43351 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18594621 | 0.85 | SCN9A (0.67) | SCN9AKCNH2SCN5APLK4AURKA | |
| SCHEMBL27819569 | 0.84 | SCN9A (0.67) | SCN9AKCNH2SCN5AAURKACDK1 | |
| SCHEMBL12346572 | 0.83 | SCN9A (0.60) | SCN9AKCNH2SCN5ASYK | |
| Hydrochloric Acid SCHEMBL28306332 | 0.83 | SCN9A (0.71) | SCN9AKCNH2SCN5AAURKACDK1 | |
| SCHEMBL12346576 | 0.82 | SCN9A (0.64) | SCN9AKCNH2SCN5ASYKAURKA | |
| SCHEMBL19575358 | 0.81 | AURKA (0.57) | SCN9AKCNH2SCN5ASYKPLK4 | |
| SCHEMBL10177401 | 0.81 | SCN9A (0.84) | SCN9AKCNH2SCN5ASYKCDK4 | |
| SCHEMBL14878933 | 0.81 | SCN9A (0.62) | SCN9AKCNH2SCN5AAURKACDK1 | |
| SCHEMBL10187336 | 0.81 | SCN9A (0.71) | SCN9AKCNH2SCN5AIKBKBMEN1 | |
| Hydrochloric Acid SCHEMBL12813129 | 0.80 | SCN9A (0.60) | SCN9AKCNH2SCN5ASYKPLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210276960-A1 | INHIBITORS OF TISSUE TRANSGLUTAMINASE 2 (TG2) AND USES THEREOF | NORTHWESTERN UNIVERSITY | 2021-09-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210276960-A1 | INHIBITORS OF TISSUE TRANSGLUTAMINASE 2 (TG2) AND USES THEREOF | TGM2, TGM3, TGM6 | SCN9A 4248/4885KCNH2 4781/4885SCN5A 4500/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.