Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 3/20 | 0.53 |
| ▸ | ACE | P12821 | 3/20 | 0.52 |
| ▸ | TACR1 | P25103 | 1/20 | 0.51 |
| ▸ | BCHE | P06276 | 5/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | MME | P08473 | 1/20 | 0.50 |
| ▸ | CPA1 | P15085 | 1/20 | 0.50 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.50 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.49 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.49 |
| ▸ | PPARG | P37231 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | CTSS | P25774 | 1/20 | 0.48 |
| ▸ | CTSK | P43235 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19155424 | 1.00 | PPARA (0.53) | PPARAACETACR1BCHEPTPN1 | |
| SCHEMBL28906216 | 0.93 | TACR1 (0.55) | PPARATACR1BCHEMEN1KMT2A | |
| SCHEMBL19155378 | 0.93 | TACR1 (0.55) | PPARATACR1BCHEMEN1KMT2A | |
| SCHEMBL17772599 | 0.88 | PPARA (0.54) | PPARAACEPTPN1MMECPA1 | |
| SCHEMBL17772589 | 0.88 | PPARA (0.54) | PPARAACEPTPN1MMECPA1 | |
| SCHEMBL17772603 | 0.88 | PPARA (0.54) | PPARAACEPTPN1MMECPA1 | |
| SCHEMBL2584592 | 0.87 | ACE (0.61) | PPARAACETACR1PTPN1MME | |
| SCHEMBL8964028 | 0.86 | BCHE (0.55) | ACEBCHEMEN1KMT2AMME | |
| SCHEMBL8964021 | 0.86 | BCHE (0.55) | ACEBCHEMEN1KMT2AMME | |
| SCHEMBL17773464 | 0.86 | ITGB3 (0.49) | ACETACR1PTPN1ITGA4ITGB7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112313222-B | Tetrahydroisoquinoline derivative, preparation method and application thereof | 浙江海正药业股份有限公司 | 2024-01-26 | — | — | CN | disclosed |
| US-20230242522-A1 | SALT OF TETRAHYDROISOQUINOLINE DERIVATIVE, PREPARATION METHOD THEREFOR, AND MEDICAL USE THEREOF | ZHEJIANG HISUN PHARMACEUTICAL CO., LTD. (CN) | 2023-08-03 | — | — | US | disclosed |
| EP-4177253-A1 | TETRAHYDROISOQUINOLINE DERIVATIVE, PREPARATION METHOD THEREFOR, AND MEDICAL USE THEREOF | Zhejiang Hisun Pharmaceutical Co., Ltd. (CN) | 2023-05-10 | — | — | EP | disclosed |
| US-11384097-B2 | Tetrahydroisoquinoline derivative, preparation method therefor and use thereof | ZHEJIANG HISUN PHARMACEUTICAL CO., LTD. (CN) | 2022-07-12 | — | — | US | disclosed |
| CN-113880825-A | Salt of tetrahydroisoquinoline derivative, preparation method and medical application thereof | 浙江海正药业股份有限公司 | 2022-01-04 | — | — | CN | disclosed |
| US-20210277021-A1 | TETRAHYDROISOQUINOLINE DERIVATIVE, PREPARATION METHOD THEREFOR AND USE THEREOF | ZHEJIANG HISUN PHARMACEUTICAL CO., LTD. (CN) | 2021-09-09 | — | — | US | disclosed |
| CN-112313222-A | Tetrahydroisoquinoline derivatives, preparation method and application thereof | 浙江海正药业股份有限公司 | 2021-02-02 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11384097-B2 | Tetrahydroisoquinoline derivative, preparation method therefor and use thereof | AGTR2, AGTR1, AVPR2 | PPARA 1761/4885ACE 17/4885TACR1 28/4885 |
| US-20230242522-A1 | SALT OF TETRAHYDROISOQUINOLINE DERIVATIVE, PREPARATION METHOD THEREFOR, AND MEDICAL USE THEREOF | AGTR2, AGTR1, SLC5A11 | PPARA 1466/4885ACE 17/4885TACR1 69/4885 |
| US-20210277021-A1 | TETRAHYDROISOQUINOLINE DERIVATIVE, PREPARATION METHOD THEREFOR AND USE THEREOF | AGTR2, AGTR1, AVPR2 | PPARA 1761/4885ACE 17/4885TACR1 28/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.