Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.66 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.66 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.66 |
| ▸ | NPC1 | O15118 | 2/20 | 0.66 |
| ▸ | RAB9A | P51151 | 2/20 | 0.66 |
| ▸ | BRD4 | O60885 | 4/20 | 0.62 |
| ▸ | BRD3 | Q15059 | 3/20 | 0.62 |
| ▸ | BRD2 | P25440 | 2/20 | 0.62 |
| ▸ | BRDT | Q58F21 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.53 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.53 |
| ▸ | BPTF | Q12830 | 1/20 | 0.53 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.53 |
| ▸ | BRD7 | Q9NPI1 | 1/20 | 0.53 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20271467 | 1.00 | MAPT (0.66) | MAPTTDP1MAPK1NPC1RAB9A | |
| SCHEMBL11242226 | 0.84 | BRD4 (0.64) | MAPTNPC1RAB9ABRD4BRD3 | |
| SCHEMBL11242221 | 0.84 | BRD4 (0.64) | MAPTNPC1RAB9ABRD4BRD3 | |
| SCHEMBL20271560 | 0.80 | MAPT (0.67) | MAPTTDP1MAPK1NPC1RAB9A | |
| SCHEMBL23787111 | 0.80 | MAPT (0.67) | MAPTTDP1MAPK1NPC1RAB9A | |
| SCHEMBL20271917 | 0.76 | BRD4 (1.00) | MAPK1BRD4BRD3BRD2BRDT | |
| SCHEMBL20271914 | 0.76 | BRD4 (1.00) | MAPK1BRD4BRD3BRD2BRDT | |
| SCHEMBL11245402 | 0.75 | NPC1 (0.62) | MAPTTDP1MAPK1NPC1RAB9A | |
| SCHEMBL11245399 | 0.75 | NPC1 (0.62) | MAPTTDP1MAPK1NPC1RAB9A | |
| SCHEMBL15496642 | 0.74 | BRD4 (0.66) | MAPTBRD4BRD3BRD2BRDT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3554503-B1 | INHIBITORS OF BROMODOMAIN-CONTAINING PROTEIN 4 (BRD4) | UNIV TEXAS (US) | 2023-10-04 | — | — | EP | disclosed |
| US-11117865-B2 | Inhibitors of bromodomain-containing protein 4 (BRD4) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2021-09-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11117865-B2 | Inhibitors of bromodomain-containing protein 4 (BRD4) | BRD4, NFKBIA, NFRKB | MAPT 1988/4885TDP1 2864/4885MAPK1 680/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.