Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.67 |
| ▸ | NPC1 | O15118 | 2/20 | 0.67 |
| ▸ | RAB9A | P51151 | 2/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 6/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | PHLPP2 | Q6ZVD8 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 3/20 | 0.52 |
| ▸ | PKM | P14618 | 3/20 | 0.51 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.51 |
| ▸ | CASP3 | P42574 | 1/20 | 0.51 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.51 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.51 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20271560 | 1.00 | MAPT (0.67) | MAPTTDP1NPC1RAB9AMAPK1 | |
| SCHEMBL20271467 | 0.80 | MAPT (0.66) | MAPTTDP1NPC1RAB9AMAPK1 | |
| SCHEMBL23787102 | 0.80 | MAPT (0.66) | MAPTTDP1NPC1RAB9AMAPK1 | |
| SCHEMBL8843749 | 0.80 | PHLPP2 (0.75) | PHLPP2POLBBRD4 | |
| SCHEMBL8843743 | 0.80 | PHLPP2 (0.75) | PHLPP2POLBBRD4 | |
| SCHEMBL9616947 | 0.74 | ALDH1A1 (0.69) | MAPTTDP1NPC1RAB9AMAPK1 | |
| SCHEMBL1046239 | 0.72 | USP2 (0.76) | MAPTTDP1NPC1RAB9AALDH1A1 | |
| SCHEMBL436674 | 0.72 | PKM (0.89) | TDP1ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL13901737 | 0.72 | USP2 (0.74) | ALDH1A1LMNAMEN1KMT2AGAA | |
| SCHEMBL20271957 | 0.71 | BRD4 (0.68) | ALDH1A1LMNAMEN1KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3554503-B1 | INHIBITORS OF BROMODOMAIN-CONTAINING PROTEIN 4 (BRD4) | UNIV TEXAS (US) | 2023-10-04 | — | — | EP | disclosed |
| US-11117865-B2 | Inhibitors of bromodomain-containing protein 4 (BRD4) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2021-09-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11117865-B2 | Inhibitors of bromodomain-containing protein 4 (BRD4) | BRD4, NFKBIA, NFRKB | MAPT 1988/4885TDP1 2864/4885NPC1 1502/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.