Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGM2 | P21980 | 1/20 | 0.67 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.64 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.62 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23788965 | 0.96 | TGM2 (0.64) | TGM2SLC2A1TAAR1LRRK2RAB9A | |
| SCHEMBL23788970 | 0.86 | TGM2 (0.78) | TGM2SLC2A1TAAR1RAB9ANPC1 | |
| SCHEMBL23789082 | 0.80 | TGM2 (1.00) | TGM2SLC2A1TAAR1RAB9ANPC1 | |
| SCHEMBL23788966 | 0.79 | TGM2 (0.59) | TGM2SLC2A1TAAR1SMN1; SMN2LMNA | |
| SCHEMBL23789090 | 0.78 | TGM2 (0.73) | TGM2SLC2A1TAAR1RAB9ANPC1 | |
| SCHEMBL23788988 | 0.77 | SLC2A1 (0.68) | TGM2SLC2A1TAAR1RAB9ANPC1 | |
| SCHEMBL23788964 | 0.76 | TAAR1 (0.69) | TGM2SLC2A1TAAR1RAB9ANPC1 | |
| SCHEMBL23789091 | 0.75 | TGM2 (0.84) | TGM2SLC2A1TAAR1RAB9ANPC1 | |
| SCHEMBL23789092 | 0.74 | TGM2 (0.84) | TGM2SLC2A1TAAR1RAB9ANPC1 | |
| SCHEMBL6457629 | 0.72 | MCHR1 (0.55) | KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210276960-A1 | INHIBITORS OF TISSUE TRANSGLUTAMINASE 2 (TG2) AND USES THEREOF | NORTHWESTERN UNIVERSITY | 2021-09-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210276960-A1 | INHIBITORS OF TISSUE TRANSGLUTAMINASE 2 (TG2) AND USES THEREOF | TGM2, TGM3, TGM6 | TGM2 1/4885SLC2A1 550/4885TAAR1 4661/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.