Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.69 |
| ▸ | TGM2 | P21980 | 1/20 | 0.64 |
| ▸ | SLC2A1 | P11166 | 4/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 3/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.48 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.46 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.46 |
| ▸ | KCNH3 | Q9ULD8 | 3/20 | 0.46 |
| ▸ | DNM2 | P50570 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13329971 | 0.81 | LMNA (0.64) | TAAR1SLC2A1KCNH2MAPTLMNA | |
| SCHEMBL3233135 | 0.80 | MAPT (0.59) | TAAR1TGM2SLC2A1MAPTLMNA | |
| SCHEMBL23789082 | 0.78 | TGM2 (1.00) | TAAR1TGM2SLC2A1LMNAKDM4E | |
| SCHEMBL12485120 | 0.77 | TAAR1 (0.72) | TAAR1TGM2SLC2A1KCNH2MAPT | |
| SCHEMBL23788967 | 0.76 | TGM2 (0.67) | TAAR1TGM2SLC2A1MAPTLMNA | |
| SCHEMBL23789090 | 0.76 | TGM2 (0.73) | TAAR1TGM2SLC2A1KCNH2MAPT | |
| SCHEMBL23788970 | 0.75 | TGM2 (0.78) | TAAR1TGM2SLC2A1KCNH2MAPT | |
| SCHEMBL23780651 | 0.74 | TAAR1 (0.72) | TAAR1TGM2SLC2A1KCNH2MAPT | |
| SCHEMBL23788965 | 0.74 | TGM2 (0.64) | TAAR1TGM2SLC2A1KDM4EHTT | |
| SCHEMBL3244336 | 0.73 | MAPT (0.57) | TAAR1TGM2SLC2A1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210276960-A1 | INHIBITORS OF TISSUE TRANSGLUTAMINASE 2 (TG2) AND USES THEREOF | NORTHWESTERN UNIVERSITY | 2021-09-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210276960-A1 | INHIBITORS OF TISSUE TRANSGLUTAMINASE 2 (TG2) AND USES THEREOF | TGM2, TGM3, TGM6 | TAAR1 4661/4885TGM2 1/4885SLC2A1 550/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.