Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | FBP1 | P09467 | 2/20 | 0.36 |
| ▸ | ABL1 | P00519 | 2/20 | 0.36 |
| ▸ | BRAF | P15056 | 2/20 | 0.35 |
| ▸ | PDE4A | P27815 | 2/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23792344 | 0.90 | RAB9A (0.39) | NPC1LMNAPOLBRAB9APTGDR2 | |
| SCHEMBL23782532 | 0.86 | POLB (0.42) | NPC1LMNAPOLBRAB9ASMN1; SMN2 | |
| SCHEMBL18282064 | 0.86 | LMNA (0.42) | NPC1LMNAPOLBRAB9ASMN1; SMN2 | |
| SCHEMBL23782388 | 0.86 | NPC1 (0.41) | NPC1LMNAPOLBRAB9APTGDR2 | |
| SCHEMBL30173718 | 0.86 | NPC1 (0.41) | NPC1LMNAPOLBRAB9APTGDR2 | |
| SCHEMBL30173771 | 0.85 | PTGDR2 (0.53) | NPC1LMNARAB9APTGDR2ESR1 | |
| SCHEMBL23782514 | 0.85 | PTGDR2 (0.53) | NPC1LMNARAB9APTGDR2ESR1 | |
| SCHEMBL23791891 | 0.84 | NPC1 (0.40) | NPC1LMNAPOLBRAB9APTGDR2 | |
| SCHEMBL26240299 | 0.83 | GRN (0.40) | NPC1LMNAPOLBRAB9APTGDR2 | |
| SCHEMBL23792015 | 0.82 | GRN (0.40) | NPC1LMNAPOLBRAB9APTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021178488-A1 | EIF4E INHIBITORS AND USES THEREOF | PIC Therapeutics, Inc. (US) | 2021-09-10 | — | — | WO | disclosed |