Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | SCN4A | P35499 | 1/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | IGF1R | P08069 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | GCK | P35557 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23794884 | 0.83 | NPC1 (0.54) | POLBMAPK10NPC1RAB9ALMNA | |
| SCHEMBL9820200 | 0.81 | NPC1 (0.46) | POLBNPC1MEN1KMT2ARAB9A | |
| SCHEMBL23794881 | 0.81 | NPC1 (0.62) | MAPK10NPC1MEN1KMT2ARAB9A | |
| SCHEMBL23794883 | 0.81 | DHODH (0.49) | NPC1LRRK2 | |
| SCHEMBL20008777 | 0.80 | MEN1 (0.44) | SCN4AMAPK10NPC1MEN1KMT2A | |
| SCHEMBL15885953 | 0.79 | MKNK1 (0.43) | POLBNPC1RAB9ALMNALRRK2 | |
| SCHEMBL9820240 | 0.79 | NPC1 (0.46) | NPC1MEN1KMT2ARAB9ALMNA | |
| SCHEMBL9820163 | 0.79 | ABCB11 (0.61) | POLBNPC1MEN1KMT2ARAB9A | |
| SCHEMBL15688182 | 0.77 | LRRK2 (0.44) | SCN4AMAPK10LMNAMAPK1IGF1R | |
| SCHEMBL181171 | 0.76 | LRRK2 (0.40) | MAPK10NPC1RAB9ALMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3876933-A1 | NEUTROPHIL INFLAMMATION INHIBITOR AND USES THEREOF | Chang Gung University of Science and Technology (TW) | 2021-09-15 | — | — | EP | disclosed |