Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.62 |
| ▸ | RAB9A | P51151 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | IGF1R | P08069 | 1/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23794884 | 0.83 | NPC1 (0.54) | NPC1RAB9AMAPTSMN1; SMN2KDM4E | |
| SCHEMBL23794877 | 0.81 | POLB (0.47) | NPC1RAB9AMAPTSMN1; SMN2KDM4E | |
| SCHEMBL9820200 | 0.81 | NPC1 (0.46) | NPC1RAB9AMAPTSMN1; SMN2KDM4E | |
| SCHEMBL15885953 | 0.79 | MKNK1 (0.43) | NPC1RAB9ASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL9820240 | 0.79 | NPC1 (0.46) | NPC1RAB9AMAPTSMN1; SMN2KDM4E | |
| SCHEMBL9820163 | 0.79 | ABCB11 (0.61) | NPC1RAB9AMAPTSMN1; SMN2KDM4E | |
| SCHEMBL23794883 | 0.77 | DHODH (0.49) | NPC1 | |
| SCHEMBL21807656 | 0.77 | NPC1 (1.00) | NPC1RAB9AMAPTSMN1; SMN2KDM4E | |
| SCHEMBL21807641 | 0.77 | NPC1 (0.69) | NPC1RAB9AMAPTSMN1; SMN2KDM4E | |
| SCHEMBL24221991 | 0.77 | NPC1 (0.69) | NPC1RAB9AMAPTSMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3876933-A1 | NEUTROPHIL INFLAMMATION INHIBITOR AND USES THEREOF | Chang Gung University of Science and Technology (TW) | 2021-09-15 | — | — | EP | disclosed |