Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 3/20 | 0.49 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.43 |
| ▸ | BRAF | P15056 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 2/20 | 0.41 |
| ▸ | BCR | P11274 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.41 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.41 |
| ▸ | KIF11 | P52732 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23794877 | 0.81 | POLB (0.47) | LRRK2NPC1 | |
| SCHEMBL23794884 | 0.79 | NPC1 (0.54) | LRRK2NPC1 | |
| SCHEMBL15885953 | 0.79 | MKNK1 (0.43) | LRRK2BRAFNPC1 | |
| SCHEMBL23794881 | 0.77 | NPC1 (0.62) | NPC1 | |
| SCHEMBL9820200 | 0.77 | NPC1 (0.46) | LRRK2BRAFNPC1 | |
| SCHEMBL18131134 | 0.75 | NPC1 (0.71) | KCNH2NPC1 | |
| SCHEMBL9820240 | 0.75 | NPC1 (0.46) | NPC1 | |
| SCHEMBL9820163 | 0.75 | ABCB11 (0.61) | NPC1 | |
| SCHEMBL23019308 | 0.72 | LMNA (0.43) | LRRK2NPC1 | |
| SCHEMBL2629316 | 0.72 | KEAP1 (0.58) | KCNH2KIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3876933-A1 | NEUTROPHIL INFLAMMATION INHIBITOR AND USES THEREOF | Chang Gung University of Science and Technology (TW) | 2021-09-15 | — | — | EP | disclosed |