Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | KDM5A | P29375 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2153696 | 0.85 | PDE3B (0.41) | L3MBTL1MEN1KMT2ATSHRALDH1A1 | |
| SCHEMBL1980240 | 0.84 | ALDH1A1 (0.41) | L3MBTL1MEN1KMT2ATSHRALDH1A1 | |
| SCHEMBL16054244 | 0.84 | SNCA (0.42) | L3MBTL1MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL12959692 | 0.82 | L3MBTL1 (0.40) | L3MBTL1MEN1KMT2ATSHRALDH1A1 | |
| SCHEMBL15417774 | 0.82 | L3MBTL1 (0.41) | L3MBTL1MEN1KMT2ATSHRALDH1A1 | |
| SCHEMBL25991269 | 0.81 | PDE3B (0.39) | L3MBTL1MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL12651103 | 0.81 | KDM4E (0.41) | L3MBTL1MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL30394200 | 0.77 | TSHR (0.50) | L3MBTL1MEN1KMT2ATSHRALDH1A1 | |
| SCHEMBL8954330 | 0.77 | TSHR (0.50) | L3MBTL1MEN1KMT2ATSHRALDH1A1 | |
| SCHEMBL22188019 | 0.76 | TRPV4 (0.42) | L3MBTL1MEN1KMT2AMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3649127-B1 | SUBSTITUTED AZAINDOLINE DERIVATIVES AS NIK INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2021-09-08 | — | — | EP | disclosed |