Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRPF1 | P55201 | 16/20 | 0.49 |
| ▸ | BRD9 | Q9H8M2 | 5/20 | 0.46 |
| ▸ | BRD4 | O60885 | 4/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.46 |
| ▸ | BRD1 | O95696 | 9/20 | 0.38 |
| ▸ | BRPF3 | Q9ULD4 | 5/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19448882 | 0.81 | BRPF1 (0.50) | BRPF1BRD9BRD4CA12CA9 | |
| SCHEMBL17576626 | 0.77 | BRPF1 (0.52) | BRPF1BRD9BRD4CA12CA9 | |
| SCHEMBL30665881 | 0.77 | BRPF1 (0.52) | BRPF1BRD9BRD4CA12CA9 | |
| SCHEMBL10909054 | 0.76 | BRPF1 (0.57) | BRPF1BRD9BRD4CA12CA9 | |
| SCHEMBL3263915 | 0.74 | BRPF1 (0.57) | BRPF1BRD9BRD4CA12CA9 | |
| SCHEMBL16932310 | 0.74 | BRPF1 (0.57) | BRPF1BRD9BRD4CA12CA9 | |
| SCHEMBL30538035 | 0.74 | BRPF1 (0.57) | BRPF1BRD9BRD4CA12CA9 | |
| SCHEMBL21848211 | 0.73 | DAO (0.50) | BRPF1 | |
| SCHEMBL16364568 | 0.73 | PRKCI (0.44) | — | |
| SCHEMBL2172818 | 0.73 | BRPF1 (0.62) | BRPF1BRD9BRD4CA12CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3876928-A2 | INHIBITORS OF HISTONE DEACETYLASE USEFUL FOR THE TREATMENT OR PREVENTION OF HIV INFECTION | Merck Sharp & Dohme Corp. (US) | 2021-09-15 | — | — | EP | disclosed |