Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Gluconic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.86 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | PGD | P52209 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Gluconic Acid SCHEMBL23804123 | 1.00 | PDE4A (0.86) | PDE4ALMNAUSP2SLCO1B1L3MBTL1 | |
| Gluconic Acid SCHEMBL27590197 | 0.98 | PDE4A (0.91) | PDE4ALMNAUSP2SLCO1B1L3MBTL1 | |
| Gluconic Acid SCHEMBL1001814 | 0.98 | PDE4A (0.91) | PDE4ALMNAUSP2SLCO1B1L3MBTL1 | |
| Gluconic Acid SCHEMBL7770544 | 0.95 | PDE4A (0.86) | PDE4ALMNAUSP2SLCO1B1L3MBTL1 | |
| Gluconic Acid SCHEMBL28022593 | 0.95 | PDE4A (0.95) | PDE4ALMNAUSP2SLCO1B1L3MBTL1 | |
| Gluconic Acid SCHEMBL1532403 | 0.95 | PDE4A (0.95) | PDE4ALMNAUSP2SLCO1B1L3MBTL1 | |
| Gluconic Acid SCHEMBL6536096 | 0.95 | PDE4A (0.95) | PDE4ALMNAUSP2SLCO1B1L3MBTL1 | |
| Gluconic Acid SCHEMBL9017591 | 0.95 | PDE4A (0.95) | PDE4ALMNAUSP2SLCO1B1L3MBTL1 | |
| Gluconic Acid SCHEMBL14894063 | 0.93 | PDE4A (0.91) | PDE4ALMNAUSP2SLCO1B1L3MBTL1 | |
| Gluconic Acid SCHEMBL21462394 | 0.93 | PDE4A (0.91) | PDE4ALMNAUSP2SLCO1B1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250213644-A1 | COMPOSITIONS AND METHODS FOR TREATMENT OF BONE-RELATED DISEASE OR DISORDER | GABET, Yankel (IL) | 2025-07-03 | — | — | US | disclosed |
| EP-4392053-A1 | COMPOSITIONS AND METHODS FOR TREATMENT OF BONE-RELATED DISEASE OR DISORDER | Gabet, Yankel (IL) | 2024-07-03 | — | — | EP | disclosed |
| WO-2023026280-A1 | COMPOSITIONS AND METHODS FOR TREATMENT OF BONE-RELATED DISEASE OR DISORDER | RAMOT AT TEL-AVIV UNIVERSITY LTD. (IL) | 2023-03-02 | — | — | WO | disclosed |
| WO-2021181379-A1 | COMPOSITIONS AND METHODS FOR TREATING OSTEOLYSIS | RAMOT AT TEL-AVIV UNIVERSITY LTD. (IL) | 2021-09-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250213644-A1 | COMPOSITIONS AND METHODS FOR TREATMENT OF BONE-RELATED DISEASE OR DISORDER | BMP2, CALCB, CALCA | PDE4A 2510/4885LMNA 2800/4885USP2 3102/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.