Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSPA5 | P11021 | 10/20 | 1.00 |
| ▸ | HSPA2 | P54652 | 4/20 | 1.00 |
| ▸ | HSPA9 | P38646 | 3/20 | 1.00 |
| ▸ | HSPA1A | P0DMV8 | 1/20 | 1.00 |
| ▸ | CTSL | P07711 | 1/20 | 0.60 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.57 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | XBP1 | P17861 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23804618 | 1.00 | HSPA5 (1.00) | HSPA5HSPA2HSPA9HSPA1ACTSL | |
| SCHEMBL23818887 | 0.84 | HSPA5 (1.00) | HSPA5HSPA2HSPA9HSPA1ALMNA | |
| SCHEMBL23804606 | 0.80 | HSPA5 (0.78) | HSPA5HSPA2HSPA9HSPA1ALMNA | |
| SCHEMBL10654990 | 0.79 | CTSL (0.68) | HSPA5HSPA2HSPA9HSPA1ACTSL | |
| SCHEMBL10654984 | 0.79 | CTSL (0.68) | HSPA5HSPA2HSPA9HSPA1ACTSL | |
| SCHEMBL16993880 | 0.78 | HSPA5 (0.64) | HSPA5HSPA2HSPA9HSPA1ACTSL | |
| SCHEMBL16999340 | 0.78 | HSPA5 (0.64) | HSPA5HSPA2HSPA9HSPA1ACTSL | |
| SCHEMBL26502086 | 0.78 | PKM (0.65) | HSPA5HSPA2HSPA9HSPA1APKM | |
| SCHEMBL23804612 | 0.78 | HSPA5 (1.00) | HSPA5HSPA2HSPA9HSPA1A | |
| SCHEMBL23804615 | 0.78 | HSPA5 (0.74) | HSPA5HSPA2HSPA9HSPA1ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021183942-A1 | INHIBITORS OF HSP70 PROTEINS | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2021-09-16 | — | — | WO | disclosed |
| WO-2021183942-A1 | INHIBITORS OF HSP70 PROTEINS | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2021-09-16 | — | — | WO | disclosed |