Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 2/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.43 |
| ▸ | GFER | P55789 | 2/20 | 0.43 |
| ▸ | RHEB | Q15382 | 1/20 | 0.43 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | PHGDH | O43175 | 2/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.38 |
| ▸ | DAO | P14920 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23809377 | 0.86 | SLC9A1 (0.48) | MCL1HSD17B10SLC9A1KDM4EALDH1A1 | |
| SCHEMBL23809193 | 0.83 | GAA (0.40) | MCL1KDM4EALDH1A1HPGDMAPK1 | |
| SCHEMBL2326927 | 0.79 | MCL1 (0.57) | MCL1HSD17B10GFERRHEBSLC9A1 | |
| SCHEMBL2276306 | 0.79 | SLC9A1 (0.64) | MCL1HSD17B10GFERRHEBSLC9A1 | |
| SCHEMBL23809223 | 0.78 | NTRK1 (0.44) | MCL1ALDH1A1 | |
| SCHEMBL27017056 | 0.78 | GPR3 (0.39) | HSD17B10KDM4EALDH1A1HPGDDAO | |
| SCHEMBL23809171 | 0.78 | HSD17B10 (0.46) | MCL1HSD17B10GFERRHEBKDM4E | |
| SCHEMBL23809181 | 0.78 | GPR35 (0.45) | MCL1HSD17B10GFERRHEBKDM4E | |
| SCHEMBL19343561 | 0.78 | MCL1 (0.56) | MCL1HSD17B10GFERRHEBSLC9A1 | |
| SCHEMBL3306325 | 0.78 | MCL1 (0.56) | MCL1HSD17B10GFERRHEBSLC9A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210283138-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | VANDERBILT UNIVERSITY | 2021-09-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210283138-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | MCL1, BCL2L1, BCL9 | MCL1 1/4885HSD17B10 3627/4885GFER 3643/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.