Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | KDM4A | O75164 | 2/20 | 0.50 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.50 |
| ▸ | HIF1AN | Q9NWT6 | 1/20 | 0.50 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.48 |
| ▸ | KDM6B | O15054 | 1/20 | 0.43 |
| ▸ | KDM6A | O15550 | 1/20 | 0.43 |
| ▸ | TET3 | O43151 | 1/20 | 0.43 |
| ▸ | KDM4B | O94953 | 1/20 | 0.43 |
| ▸ | KDM5C | P41229 | 1/20 | 0.43 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.43 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.43 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.43 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.43 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.43 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.43 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.43 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23809253 | 0.88 | KDM4E (0.54) | KDM4EL3MBTL1RAB9AKDM4AEGLN1 | |
| SCHEMBL23809372 | 0.81 | L3MBTL1 (0.62) | KDM4EL3MBTL1RAB9AKDM4AEGLN1 | |
| SCHEMBL69905 | 0.80 | KDM4E (0.74) | KDM4EL3MBTL1RAB9AKDM4AEGLN1 | |
| SCHEMBL24916221 | 0.79 | ACE2 (0.42) | KDM4EL3MBTL1RAB9AKDM4AEGLN1 | |
| SCHEMBL3526280 | 0.79 | PSMD14 (0.54) | KDM4EL3MBTL1RAB9AKDM4AEGLN1 | |
| SCHEMBL29903982 | 0.79 | PSMD14 (0.54) | KDM4EL3MBTL1RAB9AKDM4AEGLN1 | |
| SCHEMBL12128843 | 0.78 | LMNA (0.45) | KDM4EL3MBTL1RAB9APSMD14ALOX12 | |
| SCHEMBL2134700 | 0.78 | PSMD14 (0.53) | KDM4EL3MBTL1RAB9AKDM4AEGLN1 | |
| SCHEMBL27610054 | 0.78 | PSMD14 (0.53) | KDM4EL3MBTL1RAB9AKDM4AEGLN1 | |
| SCHEMBL31466724 | 0.77 | KDM4E (0.65) | KDM4EL3MBTL1RAB9AKDM4AEGLN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210283138-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | VANDERBILT UNIVERSITY | 2021-09-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210283138-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | MCL1, BCL2L1, BCL9 | KDM4E 1156/4885L3MBTL1 135/4885RAB9A 2887/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.